. 2022 May 4;20(5):e3001616. doi: 10.1371/journal.pbio.3001616

Table 1. In vitro antiplasmodial activities of chloroquine, lumefantrine, and mefloquine against P. falciparum pfcrt transfectant lines.

Parasite line	IC₅₀ (nM)^a
	Chloroquine		Lumefantrine		Mefloquine
	Control	+ verapamil	Control	+ verapamil	Control	+ verapamil
C2^GC03	25 ± 1.1	26 ± 1.7	71 ± 3.5	68 ± 2.5	52 ± 1.7	50 ± 2.7
C6^7G8	84 ± 3.5^b	27 ± 1.0^c	42 ± 1.6^b	69 ± 1.8^c	29 ± 1.2^b	53 ± 2.1^c
C4^Dd2	132 ± 4.9^b	28 ± 1.1^c	45 ± 1.8^b	67 ± 1.9^c	32 ± 1.8^b	50 ± 1.9^c

^aThe IC₅₀ values are the mean ± SEM of 4 independent experiments (performed on different days), within which measurements were averaged from 3 replicates.

^bThe P values determined from a 1-way ANOVA were less than 0.001 for comparisons with the C2^GC03 line, within a control treatment.

^cThe P values determined from a 1-way ANOVA were less than 0.001 for comparisons between the control treatment and the relevant + verapamil treatment within the same line.

The data underlying this figure is supplied in S3 Data.