FIG. 2.

Sensitization by ALP in the daunomycin-resistant L. tropica line. Cell growth of MDR parasites was determined after 72 h of incubation at 28°C. Parasites were incubated with different concentrations of the ALP miltefosine (A) and edelfosine (B) in the presence (solid bars) or in the absence (open bars) of 150 μM daunomycin. The results are expressed as the percentage of growth inhibition observed in each case compared to that in the control cells (resistant parasites maintained in the presence of 150 μM daunomycin and with no ALP). Data are the means of three independent experiments performed in duplicate, and standard deviations are represented by error bars.