FIG. 4.

Sensitization of the ALP resistance in the MDR L. tropica line by the sesquiterpene C-3. Cell growth of either wild-type (triangles) or resistant (circles) Leishmania lines was determined under the conditions described in the legend to Fig. 1, after incubation with different concentrations of the ALP miltefosine (A) and edelfosine (B) and in the presence (solid symbols) or absence (open symbols) of 10 μM sesquiterpene C-3. Control cells were incubated with the same C-3 concentration. Data are means of three independent experiments performed in duplicate, and standard deviations are represented by error bars.