Fig. 2. Network modules reflect modules of bioprocesses.

(A) Global network of orthologous gene coevolution and essential (B) and nonessential (C) orthologous gene networks in S. cerevisiae and C. albicans. The “ring” of nodes in each plot is composed of orthologous genes that coevolve with very few or no other genes. (D) The essential gene subnetwork has higher transitivity and edge density values. The nonessential gene network has higher mean distance and diameter values. (E) There are five major subnetworks or orthologous gene communities illustrated by different colors; small communities (≤10 orthologous genes) are in gray. Edge width: number of coevolving orthologous gene pairs between communities; node size: number of orthologous genes in a community. Orthologous gene communities 1 to 4 cluster together; community 5 is a singleton. (F) Orthologous gene community 1 is overrepresented with essential orthologous genes. (G to I) Orthologous gene communities differ in enriched terms. MF, molecular functions; BP, biological processes. Circles: enriched GO terms; colors: −log₁₀ P values; size of circles: GO term uniqueness. Enrichment results for each orthologous gene community are reported in table S3. The figure legend is to the right of (F).