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. 2022 May 4;8(18):eabn0105. doi: 10.1126/sciadv.abn0105

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Fig. 5. — (A) S. cerevisiae and (B) C. albicans differ in chromosome number and size. (C and D) Numbers of genes with interchromosomal orthologous gene coevolution (blue), intrachromosomal (green), or both (orange). (E and F) Intrachromosomal signatures of orthologous gene coevolution corrected by number of genes on chromosome (x axis) and number of interchromosomal signatures of orthologous gene coevolution corrected by number of genes on other chromosomes (y axis). Colors represent different chromosomes, and the regression line of all chromosomes is in black. (G and H) Distances among intrachromosomal signatures of orthologous gene coevolution. (I and J) INO80, an example of how orthologous genes can coevolve with others across the genome. Outermost track: chromosomes of either yeast with chromosome 1 at the 12 o’clock position; second track: genes on plus/minus strand; third track: genes colored according to orthologous gene community. Scatter plot shows the number of coevolving orthologous genes per orthologous gene; size reflects higher values. Links depict orthologous genes coevolving with INO80 and are colored according to chromosomal location of the other orthologous gene. Colors in (E) to (H) and ideogram and link colors in (J) correspond to chromosomes [see (A) and (B)].