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. 2022 May 2;44(1):551–561. doi: 10.1080/0886022X.2022.2056486

Figure 1.

Figure 1.

The expression of miR-26a-5p is upregulated in the renal tubular cells of mice with LPS-induced septic AKI. Eight-week-old male C57BL/6 mice were injected with 10 mg/kg LPS, and their kidney tissues were collected at 24 h after LPS treatment. Control mice were injected with normal saline. All the data are expressed as the mean ± SD (n = 6), *p < 0.05. (A) Serum creatinine. (B) Blood urea nitrogen (BUN). (C) Representative images of hematoxylin-eosin (HE) staining, Scale:50μm. (D) qPCR analysis of miR-26a-5p in the kidneys of mice treated with LPS or normal saline. U6 was used as the internal loading control. (E) In situ hybridization showing increased miR-26a-5p expression in renal tubules after LPS treatment, Scale:50μm. (F) qPCR analysis showed that miR-26a-5p was induced in LPS-treated BUMPT cells. BUMPT cells were treated with LPS (100 μg/ml). U6 was used as the internal loading control. All the data are expressed as the mean ± SD (n = 6), *p < 0.05.