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. 2022 May 2;44(1):551–561. doi: 10.1080/0886022X.2022.2056486

Figure 4.

Figure 4.

Blocking miR-26a-5p promotes renal inflammation in LPS-induced septic AKI mice. An nti-miR-26a-5p agent (20 mg/kg) or negative control (NC) was administered to male C57BL/6 mice through tail vein injection two days before the LPS injection. The mice were then injected intraperitoneally with 10 mg/kg LPS, and their kidney tissues were collected at 24 h after the LPS injection. Control mice were injected with normal saline. (A) Representative immunohistochemistry staining images of F4/80 to show macrophages, Scale bar:50μm；(B) The graph shows semiquantitative F4/80 expression detected by immunohistochemical; The data are expressed as the mean ± SD (n = 6), *p < 0.05; (C-E) qPCR analysis of IL-1β, IL-6 and TNF-α mRNA in septic AKI mice. The data are expressed as the mean ± SD (n = 4), *p < 0.05. NS: not statistically significant; (F-H) Serum IL-1β, IL-6 and TNF-α detected by ELISA. The data are expressed as the mean ± SD (n = 6), *p < 0.05. NS: not statistically significant.