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Mean ranibizumab release rate in vitro with the PDS 10, 40, or 100 mg/mL. Graph shows mean ranibizumab release rates in vitro in µg/day over a period of 6 months, from PDS implants filled with ranibizumab at 10, 40, or 100 mg/mL. Dashed lines show theoretical drug release curves, calculated based on first-order drug release kinetics. Error bars show SD. Abbreviation: PDS, Port Delivery System with ranibizumab.
