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ZQL-4c suppresses Notch-Akt signaling pathways in breast cancer cells. MCF-7, MDA-MB-231, and SK-BR-3 cells were treated with 0, 0.4, 0.8, and 1.6 μmol/L ZQL-4c for 24 h. (a)–(c) The protein levels of Notch1, Notch2, mTOR, phospho-mTOR, AKT, phospho-AKT, JAK2, phospho-JAK2, STAT3, and phospho-STAT3 were detected by western blotting. Actin was used as a loading control.
