Table I.
Metabolic parameters on days 1, 3 and 5 in Mirasol-treated and control platelets
| Parameter/day | Median (IQR) | p-value | |
|---|---|---|---|
| Mirasol | Control | ||
| Volume (gr), 1 | 284 (279–290.5) | 269 (264–272) | <0.001 |
| Volume (gr), 3 | 263.5 (254–266.5) | 248 (247–252) | 0.034 |
| Volume (gr), 5 | 239.3 (229.8–251.5) | 232.3 (224.8–238.5) | 0.156 |
| p-value | <0.001 | <0.001 | |
| Concentration (10 3 /uL), 1 | 1,072 (1,004–1,130) | 1,191.5 (1,155–1,279) | 0.005 |
| Concentration (10 3 /uL), 3 | 1,087 (1,045–1,143) | 1,258 (1,209–1,327) | 0.009 |
| Concentration (10 3 /uL), 5 | 1,150 (1,088–1,218) | 1,240(1,232–1,286) | 0.024 |
| p-value | 0.218 | 0.573 | |
| pH, 1 | 7.16 (7.14–7.20) | 7.16 (7.13–7.22) | 0.820 |
| pH, 3 | 7 (6.98–7.03) | 7.29 (7.17–7.32) | <0.001 |
| pH, 5 | 6.55 (6.5–6.76) | 7.19 (7.03–7.24) | <0.001 |
| p-value | <0.001 | 0.189 | |
| pO 2 (mmHg), 1 | 37.85 (21.3–63.5) | 32.25 (20.5–50.4) | 0.791 |
| pO 2 (mmHg), 3 | 46.3 (39.5–70.3) | 51.6 (37.9–64.1) | 0.691 |
| pO 2 (mmHg), 5 | 74.5 (56.2–106.9) | 85.2 (45.2–86.9) | 0.354 |
| p-value | 0.056 | 0.117 | |
| pCO 2 (mmHg), 1 | 43.1 (37.4–46.4) | 52.4 (42.5–58.7) | 0.034 |
| pCO 2 (mmHg), 3 | 25.2 (22.9–26.4) | 24.2 (22.5–26.7) | 0.825 |
| pCO 2 (mmHg), 5 | 17.8 (16.1–18.8) | 21.4 (20.8–22) | 0.005 |
| p-value | <0.001 | <0.001 | |
| Glucose(mg/dL), 1 | 283.5 (257–298) | 310.5 (298–335) | 0.009 |
| Glucose(mg/dL), 3 | 199 (191–21) | 275 (260–285) | <0.001 |
| Glucose(mg/dL), 5 | 118 (98–136) | 243 (222–246) | <0.001 |
| p-value | <0.001 | <0.001 | |
| Lactate(mmol/L), 1 | 2.4 (1.8–2.5) | 2.7 (1.9–3) | 0.160 |
| Lactate(mmol/L), 3 | 10.8 (10.6–11) | 7.1 (6.8–9.4) | 0.013 |
| Lactate(mmol/L), 5 | 17.8 (17.3–18.8) | 11.2 (10.7–12.5) | 0.002 |
| p-value | <0.001 | <0.001 | |
| HCO 3 (mmol/L), 1 | 14.8 (13.9–15.5) | 17.7 (16.6–19.1) | 0.007 |
| HCO 3 (mmol/L), 3 | 5.8 (5.3–6.6) | 10.4 (9.7–11.5) | <0.001 |
| HCO 3 (mmol/L), 5 | 2.6 (2.5–3) | 7.8 (6–8.7) | 0.003 |
| p-value | <0.001 | <0.001 | |
| LDH(IU/L), 1 | 80 (66.5–90.5) | 123.5 (95.5–143) | 0.031 |
| LDH(IU/L), 3 | 95.5 (75.5–162.5) | 143 (110–194.5) | 0.345 |
| LDH(IU/L), 5 | 137 (103–153) | 121 (110–133) | 0.654 |
| p-value | 0.026 | 0.694 | |
p-values in bold show statistical significance (p<0.05). IQR: interquartile range; LDH: lactate dehydrogenase.