Table 2.
Anthropometric measurements, lipid profile and insulin resistance in renal transplant recipients with stable renal function and chronic allograft dysfunction (CAD) and healthy controls.
| Variables | Renal transplant recipients |
Healthy controls (n = 20) | p-valueb | |
|---|---|---|---|---|
| Stable renal function (n = 22) | CAD (n = 28) | |||
| Body mass index (kg/m2) | 24.64 ± 2.70c | 27.59 ± 1.18c | 21.55 ± 1.50 | <0.001 |
| Waist-to-hip ratio | 0.90 ± 0.06c | 1.07 ± 0.12c,d | 0.78 ± 0.05 | <0.001 |
| Total cholesterol (mg/dl) | 144.68 ± 38.02c | 220.29 ± 42.16c,d | 108.05 ± 12.54 | <0.001 |
| HDL-C (mg/dl) | 39.82 ± 3.92c | 37.21 ± 4.40c | 42.90 ± 3.88 | 0.003 |
| LDL-C (mg/dl) | 114.95 ± 15.56c | 153.36 ± 22.73c,d | 82.90 ± 7.41 | <0.001 |
| Triglycerides (mg/dl) | 173.73 ± 39.66c | 203.00 ± 25.94c,d | 98.20 ± 10.13 | <0.001 |
| Post-transplant dyslipidemia, n (%) | 3 (13.6) | 18 (64.3) | – | <0.001a |
| Fasting plasma glucose (mg/dl) | 113.91 ± 15.15c | 121.68 ± 8.41c,d | 86.85 ± 6.90 | <0.001 |
| Fasting serum insulin (μIU/ml) | 14.34 ± 6.22c | 21.81 ± 9.86c,d | 7.02 ± 2.08 | <0.001 |
| HOMA-IR | 3.55 ± 1.45c | 5.90 ± 2.73c,d | 1.36 ± 0.43 | <0.001 |
| Insulin resistance, n (%) | 15 (68.2) | 28 (100.0) | 0.002 | |
| Diabetes mellitus, n (%) | 5 (22.7) | 7 (25.0) | – | 0.853a |
Abbreviations: HDL-C: High-density lipoprotein-cholesterol; LDL-C: Low-density lipoprotein-cholesterol; HOMA-IR: Homeostasis model assessment of insulin resistance.
Continuous data are represented as mean ± SD and categorical data are represented as number and percentages.
a
Fisher's Exact test with Monte Carlo corrected significance.
b
One-way ANOVA test with post hoc test (Tukey) for pairwise comparisons.
c
Significant difference from healthy controls (p < 0.05).
d
Significant difference from renal transplant recipients with stable renal function (p < 0.05).