FIGURE 1.

BEST4⁺ cell characteristic transcripts in health and UC inflammation. Heat maps of transcripts significantly elevated in BEST4⁺ cells in (A) both studies or (B) one of the studies in healthy epithelium presented as log₂[fold change (FC)]; (C) transcripts characteristic for BEST4⁺ cells in UC inflamed epithelia. Transcripts in orange are BEST4⁺ cell-specific in both studies and thus might serve as cluster markers in health or disease. Transcripts in blue are specific to healthy BEST4⁺ cells in Oxford study; transcripts in pink are specific to healthy BEST4⁺ cells in Broad study. * – transcripts are elevated in healthy BEST4 cells in both studies, but are downregulated in active UC in the Broad study.