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. 2022 Apr;11(4):720–741. doi: 10.21037/gs-22-189

Table 1. STAT family gene expression was related to the prognosis of breast cancer in PrognoScan.

Gene Dataset Endpoint Cutpoint Cox P value Ln(HR) HR (95% CI)
STAT1 GSE7378 OS 158 0.734006 0.422818 1.53 (0.96–2.42)
E-TABM-158 OS 198 0.690165 0.102520 1.11 (0.88–1.39)
GSE19615 DFS 76 −1.49087 −0.231171 0.79 (0.44–1.42)
GSE3143 DFS 54 −15.3825 0.034494 1.04 (0.48–2.22)
GSE7849 DFS 249 0.543037 0.223837 1.25 (0.88–1.78)
GSE3494-GPL96 RFS 204 0.380639 0.121462 1.13 (0.88–1.44)
GSE4922-GPL96 RFS 87 0.570071 0.024605 1.02 (0.61–1.72)
GSE2990 RFS 159 0.856193 0.462988 1.59 (0.88–2.88)
GSE7390 RFS 125 0.729704 0.215864 1.24 (0.89–1.73)
GSE9195 DMFS 87 0.843094 0.069123 1.07 (0.80–1.43)
GSE12093 DMFS 136 1.48027 0.413829 1.51 (0.92–2.50)
GSE11121 DMFS 200 0.904803 0.225317 1.25 (0.88–1.77)
GSE1378 DMFS 286 −1.27494 −0.236758 0.79 (0.56–1.12)
GSE9893 DMFS 117 0.59709 0.058867 1.06 (0.76–1.48)
GSE2034 DMFS 125 −1.23639 −0.072966 0.93 (0.66–1.31)
STAT2 GSE3143 OS 158 0.123157 0.722624 2.06 (0.82–5.16)
GSE9893 OS 155 0.00447014 0.209301 1.23 (1.07–1.42)
GSE1456-GPL97 OS 159 0.741445 −0.133722 0.87 (0.40–1.94)
E-TABM-158 OS 117 0.604802 −0.220720 0.80 (0.35–1.85)
GSE7390 OS 198 0.671654 0.116688 1.12 (0.66–1.93)
GSE7849 DFS 76 0.89763 −0.128759 0.88 (0.12–6.25)
GSE7378 DFS 54 0.710306 −0.322114 0.72 (0.13–3.97)
GSE4922-GPL97 DFS 249 0.40129 0.303484 1.35 (0.67–2.75)
GSE12276 RFS 204 0.7863 0.055055 1.06 (0.71–1.57)
GSE6532-GPL570 RFS 87 0.706449 −0.199444 0.82 (0.29–2.31)
GSE9195 RFS 77 0.784835 0.233873 1.26 (0.24–6.77)
GSE1379 RFS 60 0.688543 0.178464 1.20 (0.50–2.86)
GSE1456-GPL96 RFS 159 0.90511 −0.027443 0.97 (0.62–1.53)
GSE1456-GPL97 RFS 159 0.391313 0.341762 1.41 (0.64–3.07)
E-TABM-158 RFS 117 0.604802 −0.220720 0.80 (0.35–1.85)
GSE2990 RFS 125 0.904064 0.032345 1.03 (0.61–1.75)
GSE7390 RFS 198 0.245853 −0.126170 0.88 (0.71–1.09)
GSE19615 DMFS 115 0.153716 −0.868095 0.42 (0.13–1.38)
GSE6532-GPL570 DMFS 87 0.695463 −0.202646 0.82 (0.30–2.25)
GSE9195 DMFS 77 0.255748 −2.201030 0.11 (0.00–4.93)
GSE12093 DMFS 136 0.956642 −0.017426 0.98 (0.52–1.84)
GSE11121 DMFS 200 0.444782 0.458926 1.58 (0.49–5.13)
GSE2034 DMFS 286 0.0981089 −0.424718 0.65 (0.40–1.08)
E-TABM-158 DMFS 117 0.190977 1.181818 3.26(0.55-19.17)
GSE2990 DMFS 125 0.767727 0.271797 1.31 (0.22–7.97)
GSE7390 DMFS 198 0.304212 0.277772 1.32 (0.78–2.24)
STAT3 GSE3143 OS 158 0.695188 −0.147051 0.86 (0.41–1.80)
GSE9893 OS 155 0.0177795 −0.366907 0.69 (0.51–0.94)
GSE1456-GPL97 OS 159 0.840228 0.104908 1.11 (0.40–3.08)
E-TABM-158 OS 117 0.918875 0.020681 1.02 (0.69–1.52)
GSE7390 OS 198 0.907517 −0.030143 0.97 (0.58–1.61)
GSE7849 DFS 76 0.0141442 1.593150 4.92 (1.38–17.56)
GSE7378 DFS 54 0.456313 −0.241100 0.79 (0.42–1.48)
GSE4922-GPL96 DFS 249 0.971322 0.007425 1.01 (0.67–1.51)
GSE12276 RFS 204 0.687901 −0.072622 0.93 (0.65–1.33)
GSE6532-GPL570 RFS 87 0.70237 −0.344585 0.71 (0.12–4.15)
GSE9195 RFS 77 0.0217172 1.335230 3.80 (1.22–11.89)
GSE1379 RFS 60 0.894997 −0.060561 0.94 (0.38–2.31)
GSE1456-GPL97 RFS 159 0.89862 −0.065406 0.94 (0.34–2.56)
E-TABM-158 RFS 117 0.918875 0.020681 1.02 (0.69–1.52)
GSE2990 RFS 62 0.0108244 −1.112200 0.33 (0.14–0.77)
GSE2990 RFS 125 0.837496 −0.048294 0.95 (0.60–1.51)
GSE2990 RFS 62 0.0378638 −0.593717 0.55 (0.32–0.97)
GSE7390 RFS 198 0.646099 0.082683 1.09 (0.76–1.55)
GSE19615 DMFS 115 0.468102 −0.499143 0.61 (0.16–2.34)
GSE6532-GPL570 DMFS 87 0.70237 −0.344585 0.71 (0.12–4.15)
GSE9195 DMFS 77 0.135511 1.010010 2.75 (0.73–10.34)
GSE9195 DMFS 77 0.144656 0.890767 2.44 (0.74–8.07)
GSE12093 DMFS 136 0.0164555 −0.532524 0.59 (0.38–0.91)
GSE11121 DMFS 200 0.0203471 −0.822380 0.44 (0.22–0.88)
GSE2034 DMFS 286 0.0157849 −0.254330 0.78 (0.63–0.95)
E-TABM-158 DMFS 117 0.117872 −0.417841 0.66 (0.39–1.11)
GSE2990 DMFS 125 0.905535 −0.036515 0.96 (0.53–1.76)
GSE2990 DMFS 54 0.0858196 −0.982659 0.37 (0.12–1.15)
GSE7390 DMFS 198 0.0827706 0.387547 1.47 (0.95–2.28)
STAT4 GSE3143 OS 158 0.638658 −0.158958 0.85 (0.44–1.66)
GSE9893 OS 155 0.0693526 0.316011 1.37 (0.98–1.93)
GSE1456-GPL96 OS 159 0.337157 −0.435590 0.65 (0.27–1.57)
E-TABM-158 OS 117 0.731327 −0.069909 0.93 (0.63–1.39)
GSE7390 OS 198 0.899221 −0.021423 0.98 (0.70–1.36)
GSE7849 DFS 76 0.898074 −0.056164 0.95 (0.40–2.23)
GSE7378 DFS 54 0.0599192 −1.718460 0.18 (0.03–1.07)
GSE4922-GPL96 DFS 249 0.531574 0.183205 1.20 (0.68–2.13)
GSE12276 RFS 204 0.370653 −0.093580 0.91 (0.74–1.12)
GSE6532-GPL570 RFS 87 0.753865 0.064398 1.07 (0.71–1.60)
GSE9195 RFS 77 0.376928 −0.541672 0.58 (0.17–1.93)
GSE1456-GPL96 RFS 159 0.598349 0.245888 1.28 (0.51–3.19)
E-TABM-158 RFS 117 0.731327 −0.069909 0.93 (0.63–1.39)
GSE2990 RFS 62 0.686218 −0.069183 0.93 (0.67–1.31)
GSE19615 DMFS 115 0.0210692 −1.539200 0.21 (0.06–0.79)
GSE6532-GPL570 DMFS 87 0.753865 0.064398 1.07 (0.71–1.60)
GSE9195 DMFS 77 0.142219 −1.103740 0.33 (0.08–1.45)
GSE12093 DMFS 136 0.774322 −0.096607 0.91 (0.47–1.76)
GSE11121 DMFS 200 0.057605 −0.581530 0.56 (0.31–1.02)
GSE2034 DMFS 286 0.0147119 −0.556861 0.57 (0.37–0.90)
E-TABM-158 DMFS 117 0.986949 −0.003965 1.00 (0.62–1.60)
GSE2990 DMFS 125 0.254872 −0.531531 0.59 (0.24–1.47)
GSE7390 DMFS 198 0.992948 −0.001456 1.00 (0.72–1.38)
STAT5A GSE3143 OS 158 0.210806 −0.2375 0.79 (0.54–1.14)
GSE9893 OS 155 0.440632 −0.185188 0.83 (0.52–1.33)
GSE1456-GPL96 OS 159 0.158685 −0.706401 0.49 (0.18–1.32)
E-TABM-158 OS 117 0.501951 −0.213658 0.81 (0.43–1.51)
GSE7390 OS 198 0.71127 −0.082341 0.92 (0.60–1.42)
GSE7849 DFS 76 0.543889 0.238656 1.27 (0.59–2.74)
GSE7378 DFS 54 0.0314761 −2.14162 0.12 (0.02–0.83)
GSE4922-GPL96 DFS 249 0.0172677 −0.825435 0.44 (0.22–0.86)
GSE12276 RFS 204 0.167323 −0.228702 0.80 (0.58–1.10)
GSE6532-GPL570 RFS 87 0.00227358 −1.144590 0.32 (0.15–0.66)
GSE9195 RFS 77 0.923972 −0.074396 0.93 (0.20–4.28)
GSE1378 RFS 60 0.248078 −0.225438 0.80 (0.54–1.17)
GSE1379 RFS 60 0.452682 −0.228444 0.80 (0.44–1.44)
GSE1456-GPL96 RFS 159 0.185957 −0.683025 0.51 (0.18–1.39)
E-TABM-158 RFS 117 0.501951 −0.213658 0.81 (0.43–1.51)
GSE2990 RFS 125 0.284496 −0.312392 0.73 (0.41–1.30)
GSE7390 RFS 198 0.763745 0.053695 1.06 (0.74–1.50)
GSE19615 DMFS 115 0.00884115 −1.729470 0.18 (0.05–0.65)
GSE6532-GPL570 DMFS 87 0.00227358 −1.144590 0.32 (0.15–0.66)
GSE9195 DMFS 77 0.48064 −0.659811 0.52 (0.08–3.23)
GSE12093 DMFS 136 0.0598301 −1.15754 0.31 (0.09–1.05)
GSE11121 DMFS 200 0.0358548 −0.681225 0.51 (0.27–0.96)
GSE2034 DMFS 286 0.00786138 −0.590146 0.55 (0.36–0.86)
E-TABM-158 DMFS 117 0.406866 −0.327397 0.72 (0.33–1.56)
GSE2990 DMFS 125 0.319595 −0.384966 0.68 (0.32–1.45)
GSE7390 DMFS 198 0.996648 −0.000910 1.00 (0.65–1.53)
STAT5B GSE12417-GPL150 OS 158 0.502612 0.243754 1.28 (0.63–2.60)
GSE12417-GPL191 OS 155 0.0739188 0.306504 1.36 (0.97–1.90)
GSE12417-GPL197 OS 159 3.15E−07 −2.43983 0.09 (0.03–0.22)
GSE12417-GPL207 OS 117 0.314488 0.276225 1.32 (0.77–2.26)
GSE12417-GPL243 OS 198 0.51792 0.142256 1.15 (0.75–1.77)
GSE12417-GPL155 DFS 76 0.633366 −0.238224 0.79 (0.30–2.10)
GSE12417-GPL204 DFS 54 0.131027 −0.90912 0.40 (0.12–1.31)
GSE12417-GPL222 DFS 249 0.0659483 −0.661075 0.52 (0.26–1.04)
GSE12417-GPL160 RFS 204 0.182215 −0.092228 0.91 (0.80–1.04)
GSE12417-GPL171 RFS 77 0.899623 −0.089730 0.91 (0.23–3.69)
GSE12417-GPL188 RFS 60 0.033972 0.459418 1.58 (1.04–2.42)
GSE12417-GPL195 RFS 159 0.0667261 −0.967095 0.38 (0.14–1.07)
GSE12417-GPL211 RFS 117 0.163118 −0.805688 0.45 (0.14–1.39)
GSE12417-GPL226 RFS 62 0.0297399 −0.866101 0.42 (0.19–0.92)
GSE12417-GPL231 RFS 125 0.419839 −0.240821 0.79 (0.44–1.41)
GSE12417-GPL242 RFS 198 0.675771 −0.083283 0.92 (0.62–1.36)
GSE12417-GPL149 DMFS 115 0.0255209 −1.57939 0.21 (0.05–0.82)
GSE12417-GPL163 DMFS 87 0.066610 0.964541 2.62 (0.94–7.35)
GSE12417-GPL180 DMFS 77 0.326454 −0.909009 0.40 (0.07–2.48)
GSE12417-GPL181 DMFS 136 0.496678 −0.283021 0.75 (0.33–1.70)
GSE12417-GPL186 DMFS 200 0.00553487 −1.30901 0.27 (0.11–0.68)
GSE12417-GPL192 DMFS 286 0.0750032 −0.465471 0.63 (0.38–1.05)
GSE12417-GPL214 DMFS 117 0.372841 −0.613899 0.54 (0.14–2.09)
GSE12417-GPL228 DMFS 125 0.458577 −0.291181 0.75 (0.35–1.61)
GSE12417-GPL229 DMFS 54 0.694294 −0.129606 0.88 (0.46–1.68)
GSE12417-GPL236 DMFS 125 0.76281 −0.215466 0.81 (0.20–3.27)
GSE12417-GPL239 DMFS 198 0.289715 0.252804 1.29 (0.81–2.06)
STAT6 GSE3143 OS 158 0.993998 −0.002656 1.00 (0.50–1.99)
GSE9893 OS 155 0.00582855 −0.217493 0.80 (0.69–0.94)
GSE1456-GPL96 OS 159 0.0581333 −0.846861 0.43 (0.18–1.03)
E-TABM-158 OS 117 0.997088 0.0010673 1.00 (0.56–1.78)
GSE7390 OS 198 0.189067 −0.177569 0.84 (0.64–1.09)
GSE7849 DFS 76 0.232317 1.06851 2.91 (0.50–6.81)
GSE7378 DFS 54 0.286081 0.703717 2.02 (0.55–7.36)
GSE4922-GPL96 DFS 249 0.0879759 −0.313232 0.73 (0.51–1.05)
GSE12276 RFS 204 0.0735396 −0.165275 0.85 (0.71–1.02)
GSE6532-GPL570 RFS 87 0.0561677 −0.971252 0.38 (0.14–1.03)
GSE9195 RFS 77 0.573397 −0.384807 0.68 (0.18–2.60)
GSE1378 RFS 60 0.361895 −0.272733 0.76 (0.42–1.37)
GSE1456-GPL96 RFS 159 0.948818 −0.013512 0.99 (0.65–1.49)
E-TABM-158 RFS 117 0.959771 0.022162 1.02 (0.43–2.42)
GSE2990 RFS 125 0.742506 −0.136701 0.87 (0.39–1.97)
GSE7390 RFS 198 0.488795 −0.142638 0.87 (0.58–1.30)
GSE19615 DMFS 115 0.309889 −0.678707 0.51 (0.14–1.88)
GSE6532-GPL570 DMFS 87 0.0561677 −0.971252 0.38 (0.14–1.03)
GSE9195 DMFS 77 0.706615 −0.232473 0.79 (0.24–2.66)
GSE12093 DMFS 136 0.205107 −0.73496 0.48 (0.15–1.49)
GSE11121 DMFS 200 0.000547358 −0.603841 0.55 (0.39–0.77)
GSE2034 DMFS 286 0.0381629 −0.47926 0.62 (0.39–0.97)
E-TABM-158 DMFS 117 0.300091 0.550172 1.73 (0.61–4.91)
GSE2990 DMFS 125 0.936266 −0.044824 0.96 (0.32–2.87)

OS, overall survival; DFS, disease-free survival; RFS, relapse-free survival; DMFS, disease metastasis-free survival; HR, hazard ratio; CI, confidence interval. STAT, signal transducer and activator of transcription.