Table 5.
Univariate analysis of the clinical factors influencing the efficacy of H. pylori eradication therapy in per protocol analyses.
| Principle parameter | Case no. | Eradication Rate (%) | p-value |
|---|---|---|---|
| Age | |||
| <60 years | 123/131 | 93.9 | 0.41 |
| ≥60 years | 47/52 | 90.4 | |
| Sex | |||
| Female | 80/89 | 89.9 | 0.12 |
| Male | 90/94 | 95.7 | |
| Previous history of peptic ulcer | |||
| (−) | 152/165 | 92.1 | 0.22 |
| (+) | 18/18 | 100 | |
| HP eradication timing (per-protocol) | |||
| Group A | 86/90 | 95.6 | 0.17 |
| Group B | 84/93 | 90.3 | |
| Compliance | |||
| Good | 183/183 | 100.0 | – |
| Poor | 0 | ||
| H. pylori culture (n = 79) | |||
| Single amoxicillin resistance | 0 | – | – |
| Single clarithromycin resistance (+) | 9/12 | 75.0 | 0.05 |
| Single clarithromycin resistance (−) | 62/67 | 92.5 | |
| Single metronidazole resistance (+) | 20/26 | 76.9 | 0.008 |
| Single metronidazole resistance (−) | 51/53 | 96.2 | |
| Dual clarithromycin and metronidazole resistance (+) | 3/6 | 50.0 | <0.001 |
| Dual clarithromycin and metronidazole resistance (−) | 68/73 | 93.2 | |