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. 2022 May 4;79(5):281. doi: 10.1007/s00018-022-04296-0

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Snapshots comparing the initial structure with the most representative structure for the B-Raf/MEK1 and KSR1/MEK1 heterodimers. The N-lobes in B-Raf and MEK1 move towards each other while the N-lobes of KSR1 and MEK1 move apart. Cartoon drawings of the initial configuration (white) and a representative snapshot of the active wild-type B-Raf/MEK1 (blue/yellow), inactive wild-type B-Raf/MEK1 (gray/yellow) and KSR1/MEK1 (orange/yellow) systems. b First normal mode of every other residue for the same systems as above. c Total contact area, C-lobe to C-lobe contact area, and N-lobe to N-lobe contact area for active wild-type B-Raf/MEK1 (Act WT), inactive wild-type B-Raf/MEK1 (Inact WT) and KSR1/MEK1 (KSR) systems