Table 1.

Biochemical results from AVS

	Peripheral	Left adrenal	Right adrenal	SI Left	SI Right	LI L/R ratio	LI R/L ratio
Patient 1
Cortisol [µg/dl]	6.4	28.1	27.6	4.4	4.3	1.0
Aldosterone [ng/l]	78.7	342.3	241.8	4.3	3.1		1.4
Metanephrine [pg/ml]
Normetanephrine [pg/ml]
DHEA-S [µg/ml]	2.6	2.9	3.1	1.1	1.2	1.1
Androstenedione [ng/ml]
Patient 2
Cortisol [µg/dl]	15.1	106	35.8	7.0	2.4	3.0
Aldosterone [ng/l]
Metanephrine [pg/ml]
Normetanephrine [pg/ml]
DHEA-S [µg/ml]	<0.1	<0.1	0.2	1	4	11.8
Androstenedione [ng/ml]
Patient 3
Cortisol [µg/dl]	16.8	44.3	32.8	2.6	2.0	1.4
Aldosterone [ng/l]	<35	58.2	83.2	3.3	4.8	1.9
Metanephrine [pg/ml]
Normetanephrine [pg/ml]
DHEA-S [µg/ml]
Androstenedione [ng/ml]
Patient 4
Cortisol [µg/dl]	22.9	127.2	125.7	5.6	5.5	1.0
Aldosterone [ng/l]	<35	110	116	6.3	6.6	1.1
Metanephrine [pg/ml]	<36	87	365	4.8	20.3	4.2
Normetanephrine [pg/ml]	<48	52	100	2.2	4.2	1.9
DHEA-S [µg/ml]
Androstenedione [ng/ml]
Patient 5
Cortisol [µg/dl]	12.9	37.7	271.9	2.9	21.1		7.2
Aldosterone [ng/l]	<35	1720	272	98.3	15.5		45.6
Metanephrine [pg/ml]
Normetanephrine [pg/ml]
DHEA-S [µg/ml]
Androstenedione [ng/ml]
Patient 6
Cortisol [µg/dl]	10.8	512	616.8	47.4	57.1		1.2
Aldosterone [ng/l]
Metanephrine [pg/ml]	<36	5987	2288	332.6	127.1		3.2
Normetanephrine [pg/ml]	66	1617	568	24.5	8.6		3.4
DHEA-S [µg/ml]
Androstenedione [ng/ml]
Patient 7
Cortisol [µg/dl]	8.6	38.9	216.9	4.5	25.2		5.6
Aldosterone [ng/l]
Metanephrine [pg/ml]	40	88	2105	2.2	52.6	4.3
Normetanephrine [pg/ml]	<48	<48	552	1.0	23	4.1
DHEA-S [µg/ml]
Androstenedione [ng/ml]
Patient 8
Cortisol [µg/dl]	10.4	633.5	50.9	60.9	4.9	12.5
Aldosterone [pg/ml]	239	1840	2190	7.7	9.2	14.8
Metanephrine [pg/ml]	<36	2096	1005	116.4	55.8	6
Normetanephrine [pg/ml]	<48	601	371	25	15.5	7.7
DHEA-S [µg/ml]
Androstenedione [ng/ml]
Patient 9
Cortisol [µg/dl]	7.8	179	17	22.9	2.2	10.5
Aldosterone [ng/l]	<35	179	220	10.2	12.6	12.9
Metanephrine [pg/ml]
Normetanephrine [pg/ml]
DHEA-S [µg/ml]
Androstenedione [ng/ml]
Patient 10
Cortisol [µg/dl]	11.7	41.3	271.7	3.5	23.2		6.6
Aldosterone [pg/ml]	86	140	357	1.6	4.2		2.6
Metanephrine [pg/ml]
Normetanephrine [pg/ml]
DHEA-S [µg/ml]
Androstenedione [ng/ml]	<0.24	9.4	24.24	78.3	202		2.6
Patient 11
Cortisol [µg/dl]	14.5	154.8	32.4	10.7	2.2	4.8
Aldosterone [pg/ml]	94	1270	329	13.5	3.5	1.2
Metanephrine [pg/ml]
Normetanephrine [pg/ml]
DHEA-S [µg/ml]
Androstenedione [ng/ml]	0.66	7.94	7.25	12.0	11.0	4.4
Patient 12
Cortisol [µg/dl]	9.0	23.7	39.7	2.6	4.4		1.7
Aldosterone [pg/ml]	52	239	277	4.6	5.3		1.4
Metanephrine [pg/ml]
Normetanephrine [pg/ml]
DHEA-S [µg/ml]
Androstenedione [ng/ml]
Patient 13
Cortisol [µg/dl]	10.6	35.6	22.0	3.4	2.1	1.6
Aldosterone [ng/l]	37	63	315	1.7	8.5	8.1
Metanephrine [pg/ml]
Normetanephrine [pg/ml]
DHEA-S [µg/ml]
Androstenedione [ng/ml]
Patient 14
Cortisol [µg/dl]	12.4	74.3	46.9	6.0	3.8	1.6
Aldosterone [ng/l]	37	1415	420	38.2	11.4		2.1
Metanephrine [pg/ml]
Normetanephrine [pg/ml]
DHEA-S [µg/ml]
Androstenedione [ng/ml]
Patient 15
Cortisol [µg/dl]	8.5	28.8	56.5	3.4	6.6		2.0
Aldosterone [ng/l]	47	1008	>1320	21.4	28.1		1.5
Metanephrine [pg/ml]	<28	2410	1770	172	126		2.7
Normetanephrine [pg/ml]	57	663	503	11.6	8.8		2.6
DHEA-S [µg/ml]	0.18	0.23	0.24	1.3	1.3		1.9
Androstenedione [ng/ml]
Patient 16
Cortisol [µg/dl]	16.6	48.8	>75	2.9	4.5		1.5
Aldosterone [ng/l]	<37	311	667	16.8	36.1	1.4
Metanephrine [pg/ml]	995	47	47	0.0	0.0		1.5
Normetanephrine [pg/ml]	210	68	40	0.3	0.2		2.6
DHEA-S [µg/ml]	0.04	0.06	0.11	1.5	2.8	1.2
Androstenedione [ng/ml]

Lower limits of quantification: Cortisol 2 µg/dl, Aldosterone: 35 ng/ml, Metanephrine: 36 pg/ml, Normetanephrine: 48 pg/ml, DHEA-S 0.1 µg/ml, Androstenedione 0.24 ng/ml. When the concentration of the measured hormones was below the lower limit of quantification of the assay, half of the lower limit of quantification was used for calculation. Hormone concentrations above the upper limit of quantification were reported as the upper limit of quantification. The LI, which was used for the interpretation of its patient’s AVS, is marked bold. The patients’ 4 AVS was considered as bilateral, because the lateralization indices adjusted for aldosterone and normetanephrines were 1.9 and 1.1 (despite the lateralization index adjusted for metanephrines of 4.2)

SI Selectivity index, LI Lateralization index, L Left, R Right