Table 3.

Literature review

Study	Year	Number of patients	Indication for AVS	Dexa- methasone supression	Reference hormone	Definition of correct drainage	Definition of lateralization
Papakokkinou et al. [19]	2019	10	Bilateral adrenal incidentaloma and hypercortisolism	Yes	Aldosterone (N = 10), DHEA-S (N = 10), Epinephrine (N = 8), Norepinephrine (N = 8)	Adrenal to peripheral vein ratio of aldosterone >2	Side to side ratio of Cortisol and reference hormone >2
Ueland et al. [17]	2018	34	Adrenal incidentaloma (uni- and bilateral) and autonomous cortisol secretion	Yes	Metanephrine	Adrenal to peripheral vein ratio of metanephrine >12	Side to side ratio of absolute cortisol >2,3
Acharya et al. [20]	2018	8	Bilateral adrenal Incidentaloma	Study protocol of Young et al. [21]
Seki et al. [22]	2015	3	Bilateral adrenal masses and ACTH-independent CS	No (but ACTH stimulation)	Aldosterone (for evaluation of PA)	Not defined	Not defined
Young et al. [21]	2007	10	Bilateral adrenal incidentaloma and overt or subclinical CS	Yes	Epinephrine	Epinephrine concentration in adrenal vein exceeding periphery by 100 pg/ml	Side to side ratio of absolute cortisol >2,3
Rubinstein et al. (present study)	2021	16	PBMAH	No	Aldosterone (N = 13), Metanephrine (N = 6), Normetanephrine (N = 6), DHEA-S (N = 4), Androstenedione (N = 2)	Adrenal to peripheral vein ratio of cortisol or “reference home” >2	Side to side ratio of Cortisol and reference hormone >4

Literature review of studies of AVS performed in the setting of hypercortisolism (with at least three patients). Case reports on single patients were excluded

CS Cushing’s syndrome, PA Primary aldosteronism