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. 2022 May 4;13:2439. doi: 10.1038/s41467-022-30116-x

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Fig. 8 — Schematic of filopodial actin bundle in a rigid (a) and flexible (b) state. As cofilactin filaments permeate the fascin-linked region of the filament, they competitively dislodge fascin cross-linkers and increase the flexibility of filopodial bundles. In the proximal region of the bundles, cofilactin filaments prevail and are cross-linked through either cofilin oligomers/self-association or by some, as of yet, unknown cross-linker.