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. 2022 May 4;5:413. doi: 10.1038/s42003-022-03344-6

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Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — During inflammation in a non-lymphoid organ, activated resident immunofibroblasts and DCs upregulate ICOSL, which interacts with the locally recruited ICOS+ T cell contributing to their secretion of LTα. Engagement of LTα3 with TNFR1/2 on immunofibroblasts induces CCL19 and CCL21 chemokine production that is crucial for the positive feedback loop involved in TLS formation.