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. 2022 May 4;12:7302. doi: 10.1038/s41598-022-10776-x

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(A) Probability distribution of center of mass distance between N and C termini of HepI in the apo (purple), substrate (green), substrates with Streptomycin (red), substrates with Tobramycin (blue), HepI binary with Tobramycin (grey), products (orange), products with Streptomycin (brown), and products with Tobramycin (cyan). (B) Binding free energy differences of Tobramycin/Streptomycin to HepI WT relative to ARG/LYS mutants.