TABLE 2.
Clinafloxacin pharmacokinetic parameter values (n = 4) following administration of single i.v. and oral doses
| Route and clinafloxacin dose (mg) | Mean (%CVa) for parameter
|
||||||||
|---|---|---|---|---|---|---|---|---|---|
| Cmax (μg/ml) | Tmax (h) | AUC∞ (μg · h/ml) | t1/2 (h) | CLR (ml/min) | Ae48% | CLi.v. (ml/min) | Vss (liters) | F (%) | |
| i.v. | |||||||||
| 25 | 0.24 (9) | 1.12 (4) | 4.6 (20) | 206 (13) | 55.4 (11) | 372 (4) | 137 (13) | ||
| 50 | 0.38 (26) | 1.82 (18) | 4.9 (6) | 342 (14) | 73.7 (8) | 468 (17) | 175 (23) | ||
| 100 | 0.90 (23) | 4.36 (25) | 5.6 (32) | 270 (24) | 67.4 (6) | 399 (22) | 150 (32) | ||
| 200 | 1.61 (16) | 8.82 (11) | 6.0 (17) | 262 (12) | 68.8 (6) | 381 (10) | 167 (18) | ||
| 400 | 3.52 (22) | 21.3 (16) | 5.8 (5) | 235 (8) | 74.8 (15) | 319 (14) | 136 (13) | ||
| Oral | |||||||||
| 25 | 0.14b (9) | 3.0b (47) | 1.17b (12) | 5.9b (31) | 221b (18) | 69.2 (15) | 92.2b (4) | ||
| 50 | 0.25 (16) | 1.8 (28) | 1.76 (16) | 5.6 (54) | 281 (17) | 57.9 (2) | 97.9 (14) | ||
| 100 | 0.77c (51) | 1.2c (58) | 4.52c (34) | 6.3c (56) | 256c (34) | 64.8c (26) | 94.4c (17) | ||
| 200 | 0.89 (20) | 1.2 (50) | 7.08 (12) | 5.9 (3) | 251 (14) | 53.4 (20) | 80.6 (9) | ||
| 400 | 2.39c (21) | 1.6c (44) | 18.5c (15) | 6.1c (23) | 232c (14) | 63.6c (4) | 86.9c (6) | ||
a
%CV, percent coefficient of variation.
b
n = 2.
c
n = 3.