TABLE 5.
Clinafloxacin pharmacokinetic parameters following oral administration every 12 h following administration of the first dose and at steady state
| Clinafloxacin dosea (mg) | Mean (%CVb) for parameter
|
|||||||
|---|---|---|---|---|---|---|---|---|
| Cmax (μg/ml) | Tmax (h) | AUC12 (μg · h/ml) | AUC∞ (μg · h/ml) | R | t1/2 (h) | CLR (ml/min) | Ae12% | |
| 100 | ||||||||
| First dose | 1.15 (33) | 1.0 (0) | 4.19 (17) | 4.78 (17) | NAd | 3.8 (11) | 158 (42) | 37.8 (28) |
| Steady state | 1.10 (26) | 1.0 (40) | 5.26 (20) | NA | 1.10 | 6.0 (10) | 184 (37) | 55.8 (31) |
| 200 | ||||||||
| First dose | 1.97 (17) | 1.5 (60) | 10.6 (18) | 12.5 (22) | NA | 4.3 (14) | 126 (31) | 39.5 (30) |
| Steady state | 2.76 (25) | 1.5 (40) | 15.3 (24) | NA | 1.22 | 5.7 (11) | 115 (37) | 52.9 (45) |
| 400 | ||||||||
| First dose | 3.43 (11) | 1.4 (29) | 19.6 (8) | 26.5 (11) | NA | 6.1 (21) | 113c (28) | 33.3c (23) |
| Steady state | 5.22 (11) | 1.3 (46) | 35.4 (23) | NA | 1.34 | 7.6 (18) | 113c (17) | 59.8c (10) |
a
For 100-, 200-, and 400-mg doses there were four, six, and six subjects, respectively.
b
%CV, percent coefficient of variation.
c
n = 5 (urine not collected from one subject).
d
NA, not applicable.