TABLE 6.
Clinafloxacin pharmacokinetic parameter values following i.v. administration of 200- and 400-mg doses every 12 h
| Clinafloxacin dosea (mg) | Mean (%CVb) for parameter
|
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cmax (μg · ml) | Tmax (h) | AUC12 (μg · h/ml) | AUC∞ (μg · h/ml) | t1/2 (h) | Cmin (μg/ml) | CLi.v. (ml/min) | CLR (ml/min) | CLNR (ml/min) | Vi.v. (liters) | Ae% | R | |
| 200 | ||||||||||||
| First dose | 2.11 (31) | 0.88 (16) | 7.81 (29) | 10.2 (33) | 5.3 (25) | NAc | 365 (35) | 185 (26) | 179 (52) | 146 (31) | 49.7 (16) | NA |
| Steady state | 2.62 (33) | 0.92 (22) | 11.0 (34) | NA | 5.04 (23) | 0.38 (55) | 335 (34) | 196 (30) | 139 (41) | NA | 59.3 (7) | 1.41 |
| 400 | ||||||||||||
| First dose | 4.22 (12) | 0.95 (12) | 16.7 (12) | 22.6 (11) | 6.23 (18) | NA | 298 (11) | 109 (34) | 189 (10) | 167 (18) | 41.6 (15) | NA |
| Steady state | 5.0 (18) | 1.05 (11) | 23.5 (17) | NA | 6.77 (11) | 0.93 (23) | 290 (18) | 135 (17) | 155 (76) | NA | 47.1 (16) | 1.41 |
a
For 200- and 400-mg doses there were six and five subjects,
b
%CV, percent-coefficient of variation
c
NA, not applicable.