TABLE 7.
Clinafloxacin pharmacokinetic parameter values (n = 8) following administration of single 186-mg i.v. and 200-mg oral doses to neutropenic subjects
| Adminstration | Mean (%CVa) for parameter
|
|||||||
|---|---|---|---|---|---|---|---|---|
| Cmax (μg/ml) | Cmax/dose [(μg/ml)/mg] | Tmax (h) | AUC∞ (μg · h/ml) | AUC∞/dose [(μg · h/ml)/mg] | t1/2 (h) | CLi.v., CLoral (ml/min) | Vi.v., Voral (liters) | |
| i.v. | 2.18 (43) | 0.0117 | 1.04 (7) | 13.4 (35) | 0.0720 | 6.82 (49) | 258 (34) | 139 (30) |
| Oral | 1.55 (29) | 0.00775 | 2.75 (55) | 12.6 (28) | 0.0630 | 5.58 (47) | 284 (29) | 130 (34) |
| Ratio | 71.1 | 66.2 | 264 | 94.0 | 87.5 | 81.8 | 110 | 93.5 |
a
%CV, percent-coefficient of variation.
b
Ratio = 100% · oral/i.v.