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. 2022 May 4;12:7213. doi: 10.1038/s41598-022-11282-w

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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(A) FTIR spectra of Alg-Fib@Nis-EDTA hydrogel and alginate polymer. (B) The swelling percentages of the Alg-Fib@Nis-EDTA hydrogel over time at various temperatures. The highest swelling percentage was at 240 (2244 ± 13%), 200 (2229 ± 9%), and 140 (2264 ± 17%) min after the incubation at 25, 37 and 42 °C, respectively. Values are mean ± SD, n = 3. SD: standard deviation. (C) Stress–strain diagram of the hydrogels after swelling in 25, 37, and 42° C using the extension rate of 5 mm/min. (D) Release profile of nisin from Alg-Fib@Nis-EDTA hydrogel compared to free nisin at different times in PBS at 37 °C. Data points are mean ± SD, (n = 3). SD: standard deviation.