Table 2.
Summary statistics of the tissue dystrophin concentration based on peptide LLQV.
| Cohort | n | Age (years) | Tissue dystrophin concentration (fmol/mg total protein) | Relative to average of control group (%) | |||||
|---|---|---|---|---|---|---|---|---|---|
| Median (Min, Max) | Mean ± SD | Median (Min, Max) | Mean ± SD | Bootstrap 95% CI for the Meana | Median (Min, Max) | Mean ± SD | Bootstrap 95% CI for the Meana | ||
| DMD | 20 | 6 (3, 10) | 6 ± 1.8 | 74.8 (14.5, 829.2) | 185.9 ± 247.0 | (91, 299) | 2.2 (0.4, 24.1) | 5.4 ± 7.2 | (3, 9) |
| BMD | 20 | 8 (3, 19) | 8 ± 4.1 | 897.2 (138.9, 2906.7) | 1089.3 ± 845.7 | (753, 1465) | 26.1 (4.0, 84.5) | 31.7 ± 24.6 | (22, 43) |
| CTRL | 20 | 9 (4, 18) | 10 ± 4.3 | 3201.4 (2231.4, 5118.9) | 3440.2 ± 857.2 | (3091, 3824) | 93.1 (64.9, 148.8) | 100 ± 24.9 | (90, 111) |
aRandom number generator state (random seed) was set at 2020 in R version 3.5.0 [45].
BMD Becker muscular dystrophy, CI confidence interval, CTRL control, DMD Duchenne muscular dystrophy, min max minimum, maximum, SD standard deviation.