Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Dec 15;38(4):342–358. doi: 10.1007/s12264-021-00800-x

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 6 — Bilateral microinjection of CNQX and AP-5 into the ACC alleviates abdominal hyperalgesia in CP rats. A Upper panel, schematic of behavioral experiment; lower panel, representative coronal section showing the sites of the cannulae in the ACC (scale bar, 2 mm). B Diagram showing the sites of the cannula tips for AP-5 (black dots) and CNQX (red dots) injection into the ACC. C Bilateral microinjections of morphine, EM-1, and EM-2 significantly increase the AWT in CP rats (n = 6 per group; ***P < 0.001, morphine vs saline; ^###P < 0.001, EM-1 vs saline; ^&&&P < 0.001, EM-2 vs saline, one-way repeated ANOVA followed by LSD post-hoc test). D, E Bilateral microinjections of CNQX (D) and AP-5 (E) on POD 14 significantly increase the AWT in CP rats but saline does not (n = 5 for saline-treated group and 6 for CNQX and AP-5-treated groups; *P < 0.05, TNBS vs sham unpaired t-test).