Fig. 1.

MI induces plasma extravasation and referred mechanical hypersensitivity in skin. A Representative images showing EB plasma extravasation (PE) points in the left forelimb (Ac) and upper-back (Ad) after MI, as compared to the control (Aa, b). B Schematics of merged PE points in the skin from control (n = 6) and MI rats (n = 9, 7 days post-MI). C Quantification of PE points in both groups (***P <0.001, independent t-test). D PE points are mainly distributed in dermatomes of the T1–T5 spinal segments. E, F Withdrawal threshold to mechanical stimulation (von Frey filaments) in the forelimb and upper-back is lower in MI rats than in controls (n = 8/group. *P <0.05, **P <0.01; ^#P <0.05, two-way ANOVA with Bonferroni test).