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Predicted additive and actual observed ED50 values for simultaneous administration of O-1966, SR144528, and morphine combinations on acute antinociception on the hotplate.
| Dose: O-1966(+SR144528)+Morphine | Effect additive | Effect observed Simultaneous administration |
| 1.25 + 3.0 | 25.1 | 9.77 |
| 2.5 + 10 | 47.4 | 17.2 |
| 5.0 + 30 | 88.1 | 18.2 |
| 10 + 100 | 100 | 70.4 |
| 20 + 300 | 100 | 78 |
