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. 2022 Apr 21;10:857230. doi: 10.3389/fcell.2022.857230

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Copyright © 2022 Gur, Edri, Moody and Fainsod.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Delayed progression through gastrulation as a result of RA biosynthesis inhibition. (A) The progression of embryos through gastrulation treated with DEAB (300 μM; n = 38) or citral (70 μM; n = 39) to inhibit RA biosynthesis. When the majority of control embryos reached early neurula (st. 14/15; n = 38), the stage distribution of the treated samples was determined. The percentage of embryos at each stage in each treatment is shown. (B) The temporal sensitivity window for the delay in gastrulation induced by inhibition of RA biosynthesis was studied by initiating the citral treatment at different developmental stages (8, n = 22; 9, n = 24; 10, n = 61; 11, n = 24). When control embryos reached early neurula (st. 15), the stage distribution of the treated samples was determined. The percentage of embryos at each stage in each treatment is shown.