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. 2022 Apr 21;13:848529. doi: 10.3389/fphar.2022.848529

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Copyright © 2022 Chen, Cai, Zhu, Wang, Gao, Yang, Mao, Zhang and Sun.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Edaravone dexborneol treatment decreases the levels of 4-HNE in neurons after SAH injury. (A,B) Representative immunofluorescence images of 4-HNE (red)/NeuN (green)-stained neurons in the basal cortex (A) and CA1 of the hippocampus (B) at 3 d after SAH. Scale bar: 20 µm. (C) The schema illustrates the regions of interest related to fluorescence staining in the brain cortex or hippocampus. (D,E) Quantitative analysis of 4-HNE + neurons in the basal cortex (D) and CA1 of the hippocampus (E) at 3 d after SAH. n = 3/group. Data are given as mean ± SE. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. Eda: edaravone; Eda dexborneol: edaravone dexborneol.