TABLE 3.
Clinafloxacin pharmacokinetic parameter values following administration of 400-mg oral doses to young and elderly healthy subjects
| Group | Mean (% CVa) for parameter
|
||||||||
|---|---|---|---|---|---|---|---|---|---|
| Cmax (μg/ml) | Tmax (h) | AUC∞ (μg · h/ml) | t1/2 (h) | CLoral (ml/min) | Voral (liters) | Ae% | CLR (ml/min) | CLNR (ml/min) | |
| Youngb (n = 16) | 3.34 (20) | 1.75 (66) | 23.5 (20) | 5.09 (16) | 296 (20) | 130 (26) | 56.3e (22) | 167e (31) | 130e (35) |
| Elderlyc (n = 16) | 3.95 (20) | 1.72 (47) | 37.0 (28) | 7.18 (15) | 193 (26) | 118 (24) | 48.2 (25) | 92 (36) | 101 (37) |
| Ratiod | 118 | 98.3 | 157 | 141 | 65.2 | 90.8 | 85.6 | 55.1 | 77.7 |
a
%CV, percent coefficient of variation.
b
Age, 18 to 35 years.
c
Age, ≥65 years.
d
Ratio calculated as (elderly/young) · 100%.
e
n = 13 due to incomplete urine collection.