TABLE 4.
Clinafloxacin pharmacokinetic parameter values by sex following administration of 400-mg oral doses to young and elderly healthy subjects
| Group | Mean (%CVa) for parameter
|
||||||
|---|---|---|---|---|---|---|---|
| Cmax (μg/ml) | Tmax (h) | AUC∞ (μg · h/ml) | t1/2z (h) | CLoral (ml/min) | Voral (liters) | CLR (ml/min) | |
| Youngb | |||||||
| Male (n = 8) | 3.02 (12) | 1.12 (39) | 19.6 (12) | 5.40 (6) | 344 (12) | 159 (12) | 195e (26) |
| Female (n = 8) | 3.61 (21) | 2.38 (56) | 27.3 (12) | 4.79 (17) | 247 (11) | 101 (12) | 135f (22) |
| Ratiod | 120 | 213 | 140 | 88.7 | 71.8 | 63.5 | 69.2 |
| Elderlyc | |||||||
| Male (n = 8) | 3.64 (17) | 1.31 (28) | 31.9 (17) | 7.58 (13) | 214 (16) | 138 (9) | 110 (22) |
| Female (n = 8) | 4.26 (20) | 2.12 (45) | 42.2 (28) | 6.78 (16) | 171 (33) | 98 (26) | 74 (42) |
| Ratiod | 117 | 162 | 132 | 89.4 | 79.9 | 71.0 | 67.2 |
a
%CV, percentage coefficient of variation.
b
Age, 18 to 35 years.
c
Age, ≥65 years.
d
Ratio calculated as (female/male) · 100%.
e
n = 7 due to incomplete urine collection.
f
n = 6 due to incomplete urine collection.