TABLE 5.
Summary of clinafloxacin pharmacokinetic parameter values following administration of single 200-mg doses to subjects with various degrees of renal dysfunction, including young and elderly subjects
| Group | Mean (%CVa) for parameter
|
|||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CLCR (ml/min) | Cmax (μg/ml) | Tmax (h) | AUC∞ (μg · h/ml) | t1/2 (h) | t1/2 duringb (h) | t1/2c post (h) | CLoral (ml/min) | Voral (liters) | Ae% | CLR (ml/min) | CLNR (ml/min) | Ad% | CLd (ml/min) | |
| CLCR ≥ 40 ml/ min (n = 39) | 76 (29) | 1.74 (23) | 1.68 (53) | 14.4 (30) | 6.25 (26) | NA | NA | 250 (28) | 130 (28) | 53.8d (23) | 135d (42) | 112d (35) | NA | NA |
| CLCR < 40 ml/ min (n = 12) | 19 (56) | 2.02 (21) | 1.42 (69) | 29.2 (28) | 12.2 (26) | NA | NA | 125 (35) | 128 (33) | 20.4 (48) | 29.2 (83) | 98.3 (24) | NA | NA |
| Hemodialysis (n = 12) | 10 (26) | 1.96 (26) | 2.92 (69) | 37.9 (22) | 14.6 (31) | 6.88 (48) | 15.0 (37) | 93 (27) | 117 (39) | 1.2 (237) | 1.1 (198) | 92 (28) | 4.0 (59) | 72 (46) |
a
%CV, percent-coefficient of variation.
b
t1/2 during, t1/2 during hemodialysis.
c
t1/2 post, t1/2 after hemodialysis was completed.
d
n = 36.