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. 2022 May 4;12:7261. doi: 10.1038/s41598-022-10788-7

Figure 4.

Figure 4

Patterns of opioid use in three-year follow-up for patients who initiated opioid therapy in 2009-2014 (n = 1,370,057). Persistent use was defined as more opioids dispensed between months 3-6 after the initial dispensed prescription.