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. 2022 May 4;12:7311. doi: 10.1038/s41598-022-11431-1

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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The optimal cut-off values of the itching period and FIB-4 index and the remarkable response rates. (a,b) The optimal cut-off values on the ROC curves in predicting remarkable response were 5 months for the itching period and 3.74 for FIB-4 index. (c,d) The remarkable response rates were 30.1% vs. 53.0% in patients with the itching period of ≥ 5 vs. < 5 months (p = 1.41 × 10⁻⁴) and 32.7% vs. 42.2% in patients with FIB-4 index of ≥ 3.74 vs < 3.74 (p = 1.38 × 10⁻⁶).