Table 2.
Univariate and multiple logistic regression analyses of factors associated with remarkable response to nalfurafine hydrochloride.
| Factor | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
| OR | 95%CI | P value | OR | 95%CI | P value | |
| Age | 0.99 | 0.97–1.01 | 0.44 | |||
| Body weight | 0.99 | 0.98–1.02 | 0.96 | |||
| Itching period | 0.96 | 0.93–0.99 | 2.70 × 10–3 | 0.96 | 0.92–0.99 | 2.10 × 10–3 |
| Baseline VAS | 1.01 | 0.99–1.03 | 0.24 | |||
| Child–Pugh class C (vs. A and B) | 0.46 | 0.24–0.89 | 2.17 × 10–2 | |||
| Hepatocellular carcinoma (presence) | 1.50 | 0.85–2.63 | 0.16 | |||
| Platelet | 1.05 | 1.03–1.09 | 2.28 × 10–4 | |||
| PT | 1.02 | 1.00–1.03 | 5.58 × 10–4 | |||
| AST | 1.00 | 0.99–1.00 | 0.23 | |||
| ALT | 1.00 | 0.99–1.00 | 0.99 | |||
| Total bilirubin | 0.97 | 0.91–1.05 | 0.48 | |||
| ALP | 1.00 | 0.99–1.00 | 0.66 | |||
| Creatinine | 1.10 | 0.95–1.28 | 0.19 | |||
| FIB-4 index | 0.84 | 0.77–0.91 | 8.07 × 10–6 | 0.83 | 0.81–0.99 | 2.08 × 10–3 |
| ALBI score | 0.57 | 0.43–0.77 | 2.02 × 10–4 | |||
OR odds ratio, CI confidence interval, VAS Visual Analog Scale, AST aspartate aminotransferase, ALT alanine aminotransferase, ALP alkaline phosphatase, FIB-4 fibrosis-4.