Table 1.
Other DUBs and cancer.
| DUB | Cancer type | Tumorigenesis | Reference |
|---|---|---|---|
| USP1 | Osteosarcoma | Promotes the invasion of osteosarcoma cells | [84] |
| Glioma | USP1 stabilizes EZH2 to activate β-catenin to drive glioma tumorigenesis | [85] | |
| Breast cancer | Regulates metastasis | [86] | |
| USP2 | Breast cancer | Promotes cell migration and invasion | [87] |
| USP4 | Breast cancer | Promotes invasion | [88] |
| Melanoma | May be an oncogene | [89] | |
| Glioblastoma | Promotes glioblastoma multiforme | [90] | |
| Facilitates chemoresistance | [91] | ||
| USP5 | Pancreatic cancer | Promotes tumorigenesis and progression | [92] |
| Non-small cell lung cancer | Upregulation of USP5 contributes to tumorigenesis | [93] | |
| Colorectal cancer | Promotes cell growth and resistance to chemotherapeutics | [94] | |
| USP7 | Medulloblastoma | Promotes medulloblastoma cell survival and metastasis | [95] |
| Breast cancer | Promotes breast carcinogenesis via stabilizing PHF8 | [96] | |
| Osteosarcoma | Promotes metastasis by inducing EMT | [97] | |
| Lung cancer | Modulates the antitumor immune response | [98] | |
| USP8 | Cervical cancer | Associated with a poor prognosis in cervical squamous cell carcinoma patients | [99] |
| Suppresses apoptosis by stabilizing FLIPL | [100] | ||
| USP10 | Colon cancer | Promotes tumor proliferation | [101] |
| Lung cancer | Inhibits cell proliferation, invasion and cell growth | [102, 103] | |
| The USP10-HDAC6 confers cisplatin resistance | [104] | ||
| Liver cancer | Promotes cell proliferation by stabilizing YAP/TAZ | [105] | |
| Promotes metastasis by stabilizing Smad4 | [106] | ||
| Inhibits p53 Signaling and constricts poor outcome | [107] | ||
| Acute myeloid leukemia | Stabilizes oncogenic FLT3 | [108] | |
| USP11 | Colorectal cancer | Promotes growth and metastasis | [109] |
| Ovarian cancer | Promotes EMT by stabilizing Snail | [110] | |
| USP13 | Non-small cell lung cancer | Promotes tumor progression | [111] |
| USP14 | Breast cancer | Regulates cell cycle progression and cell proliferation and metastasis | [112–114] |
| Enhances sensitivity to enzalutamide | [115] | ||
| USP30 | Liver cancer | Stabilizes DRP1 to promote hepatocarcinogenesis | [116] |
| UCHL1 | Gastric cancer | Promotes metastasis | [117] |
| OTUB2 | Non-small cell lung cancer | Promotes tumorigenesis | [118] |