FIGURE 3.

CR targets related to tau aggregation. (A) 18 main bioactive phytochemicals of CR and the numbers of their targets associated with tau pathogenesis. The bar diagram displays the numbers of tau pathogenesis–related targets targeted by the phytochemicals. (B) GO biological process analysis of CR targets associated with tau pathogenesis. BP terms with a p value < 0.05 were considered significant. The bar diagram displaying the numbers of tau pathogenesis–related targets of CR enriched in the different biological processes. (C) The PPI network showing the CR targets associated with the modification of tau (encoded by MAPT). Red circle node: MAPT. Cyan and green nodes represent protein modification enzymes directly or indirectly acting on MAPT, respectively. (D) Classification of protein modifying enzymes directly acting on tau protein. (E) CR phytochemicals involved in tau modification ranked according to the numbers of targets. (F) PPI network of CR targets associated with the lysosome pathway (hsa04142). The color of the node correlated with its degree value. (G) CR phytochemicals corresponding to targets involved in the lysosome pathway.