Table 5.

Possible price tiers based on the criteria of study results, quality of evidence, and comparator.

Study design	Study quality	Type of positive effect	Extent of the (additional) effect	Comparator	Price tier
Not appropriate*	Irrelevant				Not reimb.
Appropriate*	Not according to best practice	Health effect OR other care effect only	Irrelevant		Not reimb.
		Health effect AND other care effect	Irrelevant		Tier 1
	According to best practice	Other care effect (health comparable)	Irrelevant		Tier 1
		Health effect (and possibly other care effect as well)	Small	No DIHA or DiHA tier 1	Tier 1
				DiHA tier 2	Tier 2
			Considerable/substantial	No DiHA	Tier 2
				DiHA tier 1/2	Tier 3
				DiHA tier 3	Tier 4

^*Low/middle/high depending on the requirement according to Table 2.