TABLE 2.
Summary of theophylline pharmacokinetic parameter values following administration of aminophylline tablets alone or with twice-daily clinafloxacin
| Aminophylline tablet administration | Mean (%CV) for parametera
|
|||||
|---|---|---|---|---|---|---|
| Cmaxf (μg/ml) | Tmax (h) | t1/2 (h) | AUC∞f (μg · h/ml) | CLoral (ml/min) | Voral (liters) | |
| Aloneb | 4.82 (29) | 0.75 (9) | 8.42 (21) | 55.3 (28) | 49.4 (28) | 34.9 (23) |
| With 200 mg of clinafloxacinc | 4.95 (28) | 1.20 (47) | 19.0 (9) | 11.4 (27) | 26.7 (26) | 36.6 (24) |
| Ratiod | 103 | 160 | 226 | 207 | 54.1 | 105 |
| 90% CIe | 94–112 | 93.8–226 | 200–252 | 181–236 | 36.3–71.7 | 101–109 |
| With 400 mg of clinafloxacinc | 5.48 (33) | 0.95 (56) | 22.3 (23) | 145 (19) | 15.5 (21) | 36.6 (22) |
| Ratiod | 114 | 127 | 264 | 262 | 31.4 | 105 |
| 90% CIe | 104–124 | 60.5–193 | 238–290 | 229–299 | 13.8–49c | 100–109 |
a
Mean, least squares mean value; %CV, percent coefficient of variation.
b
n = 12.
c
n = 5 (one subject receiving 200 mg of clinafloxacin was withdrawn prior to theophylline pharmacokinetic sampling due to severe diarrhea, and one subject withdrew for personal reasons prior to receiving 400 mg of clinafloxacin).
d
Calculated as 100% · with clinafloxacin/alone.
e
90% CI, 90% confidence interval estimate for the ratio of with clinafloxacin/alone mean values.
f
Based on log-transformed parameter estimates.