TABLE 3.
Summary of caffeine pharmacokinetic parameter values following administration of caffeine alone and with twice-daily administration of 400 mg of clinafloxacin
| Caffeine administration | Mean (%CV) for parametera
|
|||||
|---|---|---|---|---|---|---|
| Cmaxf (μg/ml) | Tmax (h) | t1/2 (h) | AUC∞f (μg · h/ml) | CLoral (ml/min) | Voral (liters) | |
| Aloneb | 4.97 (25) | 0.83 (53) | 6.16 (35) | 47.6 (22) | 78.2 (55) | 36.9 (30) |
| With clinafloxacinc | 5.35 (42) | 1.70 (101) | 36.3 (30) | 250 (50) | 12.5 (41) | 42.5 (23) |
| Ratiod | 108 | 204 | 589 | 525 | 16.0 | 115 |
| 90% CIe | 99.5–116 | 92.8–314 | 500–679 | 121–655 | 0–44.2 | 105–125 |
a
Mean, least squares mean value; %CV, percent coefficient of variation.
b
n = 12.
c
n = 11 (one subject withdrew for personal reasons prior to receiving the second caffeine dose).
d
Calculated as 100% · with clinafloxacin/alone.
e
90% CI, 90% confidence interval estimate for the ratio of with clinafloxacin/alone treatment mean values.
f
Based on log-transformed parameter estimates.