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. 2022 Apr 21;13:858366. doi: 10.3389/fmicb.2022.858366

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Copyright © 2022 Keown, Dums, Brumm, MacDonald, Mead, Ferrell, Moore, Harrison, Polson and Wommack.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Synthesized family A DNA polymerase sequences produce proteins with diverse biochemistry. Maximum likelihood tree of four biochemically characterized references (E. coli, T. aquaticus, T7, and 3173) and 48 synthesized family A DNA polymerase amino acid sequences trimmed to the region of interest (DNA_pol_A Superfamily, acc. cl02626). Synthesized reference, viral metagenome (virome), and microbial metagenome sequences are labeled by 762 residue group (phenylalanine F) or clade (leucine, L1 or L2, or tyrosine, Y). The strength of primer extension (PE) and strand displacement (SD) activities are reflected in the bar lengths. Node values represent ultrafast bootstrap support (UFBoot) and Shimodaira-Hasegawa approximate likelihood ratio test (SH-aLRT), respectively. Scale bar represents the number of amino acid substitutions per site.