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. 2022 Apr 21;13:791248. doi: 10.3389/fmicb.2022.791248

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Copyright © 2022 Sun, Gao, Wang, Li, Wang and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of the antioxidant peptides (EP3–EP6) on HUVEC viabilities (A) and their protective effects against oxidative damage in H₂O₂-induced HUVEC model (B). Blank control refers to the viability of the normal cells without any treatment; Acetylcysteine (NAc) at the concentration of 100 μm was used as the positive control; H₂O₂ refers to H₂O₂-induced oxidative damaged model (300 μm for 6 h); NAc + H₂O₂ refers to NAc treated with H₂O₂-induced HUVECs at the concentration of 100 μm; peptide + H₂O₂ refers to EP3–EP6 treated with H₂O₂-induced HUVECs at the concentration of 200 μm, respectively. All data were presented as the mean ± SD (n = 3). (A) Values in each column have no significant difference (p > 0.05). (B) ^###p < 0.001 vs. the blank control group; ^***p < 0.001, ^**p < 0.01, and *p < 0.05 vs. the H₂O₂-treated group.