Table 3.
Mean frequencies of eQTL variants predicted to increase gene expression identified in PAGE, UKBB50k, or both for BMI and height in 1000 Genomes European and PAGE populations in whole blood
|
BMI (N = 21) |
Height (N = 110) |
||||||
|---|---|---|---|---|---|---|---|
| PAGE | Both | UKBB50k | PAGE | Both | UKBB50k | ||
| # Genes | 2 | 2 | 17 | 17 | 10 | 83 | |
| # SNPs | 30 | 62 | 354 | 525 | 215 | 2,474 | |
| 1000 Genomes European | 60.85% | 45.81% | 48.33% | 42.47% | 53.02% | 50.59% | |
| PAGE | Combined | 58.18% | 53.88% | 50.03% | 44.99% | 51.19% | 51.56% |
| African American | 55.94% | 65.90% | 49.25% | 48.61% | 53.68% | 51.46% | |
| Hispanic/Latino | 58.84% | 45.99% | 50.48% | 42.73% | 51.93% | 51.38% | |
| Asian American | 59.37% | 49.79% | 51.57% | 44.06% | 41.53% | 52.70% | |
| Native Hawaiian | 62.24% | 52.80% | 49.05% | 43.74% | 47.62% | 51.67% | |
| Native American | 59.95% | 46.46% | 49.64% | 42.41% | 51.96% | 50.92% | |
Mean allele frequencies of weighted variants oriented to a positive weight, i.e., frequency of allele predicted to increase expression of gene in whole blood. Some SNPs may be found in multiple genes, and therefore observations are not independent.