Figure 4.

Performance of the Fisher’s method to detect adaptive admixture

(A) Distributions of the combined Fisher’s score under the null hypothesis of no positive selection (H0, blue lines) and under adaptive admixture (H1, pink lines), compared to the theoretical chi-squared distribution with 4 degrees of freedom (dotted light blue line). Solid and dashed lines indicate distributions under a constant population size and a 10-fold bottleneck in the admixed population, respectively.

(B) ROC curves for F_adm, LAD, and the combined Fisher’s score under unfavorable scenarios for detecting adaptive admixture: a 10-fold bottleneck introduced in the admixed population, the use of a proxy source population having experienced strong drift (F_ST between the true source and proxy populations of 0.02), and recent admixture (T_adm = 10 generations). Only FPR < 5% are shown.