Table 1.

Summary of ${\mathit{h}}_{\mathbf{g}\mathbf{e}\mathbf{n}\mathbf{e}}^2$ estimates across 25 quantitative traits (N = 290K “White British,” UK Biobank)

Trait	Num. genes w/${\mathit{h}}_{\mathbf{gene}\mathbf{,}\mathbf{t}}^2$90%-CI > 0	Num. genes that explain$\mathbf{\ge }0.5\mathbf{\sum }{\hat{\mathbf{h}}}_{\mathbf{gene}\mathbf{,}\mathbf{t}}^2$	$h_{\mathbf{gene}\mathbf{,}\mathbf{t}}^2=h_{\mathbf{gene}\mathbf{,}\mathbf{c}}^2$	$h_{\mathbf{gene}\mathbf{,}\mathbf{t}}^2=h_{\mathbf{gene}\mathbf{,}\mathbf{lf}}^2$	$h_{\mathbf{gene}\mathbf{,}\mathbf{t}}^2=h_{\mathbf{gene}\mathbf{,}\mathbf{r}}^2$
Alkaline phosphatase	1,542	21	1,142	108	18
Apolipoprotein A-I	1,589	71	1,186	105	11
Basal metabolic rate	1,929	568	1,476	115	10
BMD heel T-score	1,297	251	1,006	76	3
BMI	1,722	677	1,312	98	6
C-reactive protein	1,561	9	1,187	88	6
Corneal hysteresis	1,103	321	833	74	3
Cystatin C	1,738	163	1,328	110	8
Forced vital capacity	1,748	565	1,337	108	5
GGT	1,650	166	1,256	101	12
Hair color	1,201	7	883	77	13
HbA1c	1,676	116	1,240	133	17
HDL	1,602	59	1,194	109	11
Height	2,258	445	1,713	152	27
High light scatter reticulocyte count	1,696	188	1,279	112	23
IGF-1	1,691	270	1,265	116	10
MCH	1,557	109	1,151	122	15
MSCV	1,585	144	1,226	101	8
Monocyte count	1,601	144	1,219	100	9
Mean platelet volume	1,753	57	1,291	127	25
Platelet count	1,748	158	1,351	102	24
Platelet distrib. width	1,598	44	1,219	102	16
RBC count	1,752	310	1,341	122	18
SHBG	1,551	7	1,164	102	17
Urate	1,584	38	1,206	103	12

Column 2: number of genes (out of 15,770) with (1) $h_{\text{gene},\text{t}}^2$ 90%-CI > 0 and (2) 90%-CI > 0 for at least one MAF bin (rare, low-frequency, or common). Column 3: estimated number of genes that explain 50% of cumulative $h_{\text{gene},\text{t}}^2$. Columns 4–6: numbers of 90%-CI > 0 genes with effects exclusively from common, low-frequency, or rare variants. (BMD, bone mineral density; MCH, mean corpuscular hemoglobin; MSCV, mean sphered corpuscular volume; RBC, red blood cell.)