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. 2022 Apr 21;12:870636. doi: 10.3389/fonc.2022.870636

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Copyright © 2022 Chen, Jia, Zhang and Zhang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The antiproliferative effects of MA and/or GE on gefitinib-resistant NSCLC cells. (A–D) The parental PC9 and H292 as well as gefitinib-resistant PC9/GR and H292/GR cells were treated with various concentrations of GE or MA; the antiproliferative effects were determined by MTT assay following 48 h of incubation. Cells were treated with GE and MA as a single agent or in combination for 48 h, and MTT assays were used to analyze the cell viability. The Chou–Talalay method was conducted to calculate the combination index (CI); a CalcuSyn software were used to analyze the data. (E–H) illustrate the combination ratio/viability, while (I–L) show the fraction affected/combination index. Data are presented for at least three independent repetitions and were illustrated as mean ± SD.