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. 2022 Apr 21;12:870636. doi: 10.3389/fonc.2022.870636

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Copyright © 2022 Chen, Jia, Zhang and Zhang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MA and GE in combination upregulated FTO-mediated MYC M6A modification. (A, B) Dot blot shows the M6A modification level in PC9/GR and H292/GR cells exposed to MA and GE for a single drug or combination. (C, D) Expression of FTO and MYC determined by Western blot assays in PC9/GR and H292/GR cells. (E, F) The m6A modification level of MYC cells was assessed by Me-RIP assay in PC9/GR and H292/GR cells exposed to MA and GE for a single drug or in combination. Data are presented for at least three independent repetitions and were illustrated as mean ± SD. *p < 0.05, ***p < 0.001.