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. 2022 Feb 23;109(4):553–570. doi: 10.1016/j.ajhg.2022.02.002

Figure 5.

Figure 5

GPR101 ectopically interacts with candidate pituitary CREs in the neo-TAD

(A) X-LAG locus, depicting the region of ectopic chromatin contacts established by GPR101 in X-LAG-affected individuals (blue box). The pituitary (Pit) and hypothalamus (Hyp) H3K27ac ChIP-seq tracks were retrieved from NCBI Gene Expression Omnibus (GEO) GSM1119175 and GSM1119152, respectively.30 Corresponding enriched open chromatin regions identified in mouse somatotropes and lactotropes are indicated by green lines (ATAC-seq tracks retrieved from GEO: GSM3579919).31 Regions with candidate enhancers that ectopically interact with GPR101 are indicated with different saturations of yellow (pituitary-specific CREs) and in red (GeneHancer-predicted CREs). The asterisk preceding the candidate GH0XJ136495 CRE (eHTATSF1) indicates an elite gene association. GPR101 putative promoter regions are indicated in purple.

(B) Enrichment of chromatin contacts from the GPR101 viewpoint with candidate enhancers (X-LAG-affected individuals versus control). Note that the eHTATSF1 CRE is only included in the duplication of subject S13.